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Immunologie > Stress Oxydant


[Stress Oxydant ]




Stress Oxydant
^

Biomarker for oxidative DNA damage

8­OHdG ELISA kit (8­hydroxy­2'­deoxyguanosine)


Formation of 8-hydroxy-2'-deoxyguanosine(8-OHdG) by oxigen radicals. H Kasai Environmental Mutagen Research,
Vol 10, p73-78(1988)
 		Oxidative stress is known to play an important role in the development of various diseases and aging process. 8­hydroxy­2'­deoxyguanosine (8­OHdG) is formed when DNA is oxidatively damaged by reactive oxygen species (ROS). 8­OHdG is one of the most sensitive biomarker for oxidative stress and can be detected in urine, serum, tissue DNA from human and animals.

1 High specificity & high sensitivity:
Cross reactivity was checked for 19 analogues.

2 Easy operation & speedy:
There is no need for expensive equipment and sample pretreatment.
Required equipments are: pipettes, incubator and micro plate reader with 450nm filter.
Assays can be completed within 3.5 hours (New 8­OHdG Check).

Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 KOG-200SE  New 8-OHdG Check ELISA kit Kit  96 puits
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 KOG-200TE  New 8-OHdG Check ELISA Trial Package (32wells) Kit  32 puits
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 KOG-HS10E  Highly Sensitive 8-OHdG Check ELISA kit Kit  96 puits
Measuring range: 0.125 to 10 ng/mL, suitable for serum* and tissue DNA.*)
*: sample pretreatment is required.


Anti 8­OHdG monoclonal antibody (clone N45.1)

Highly specific for 8­OHdG.


Epidermis from hairless mouse by chronic UVB irradiation after 4 weeks of treatment stained with N45.1.
 		Anti 8­OHdG mouse monoclonal antibody (IgG1?), lyophilized powder. Cross reactivity was checked for 19 analogues. dA, dC, dT, 2'­dG, 8­OHdA, 2'­dI, 2'­dU, O6­methyl­ dG, G, 7­methyl­G, 8­Br­G, 8­sulfhydryl­G, 4­SH­G, 8­OH­G, Gua, O6­methyl­Gua, 8­OH­Gua, uric acid, urea, creatinine, creatine (G: Guanosine, Gua: Guanine)

Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 MOG-020P  Anti 8-OHdG Mc  20 µg
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 MOG-100P  Anti 8-OHdG Mc  100 µg


Anti Thymidine Glycol (TG) monoclonal antibody

Biomarker for oxidative DNA damage

Thymidine glycol (TG) is produced when thymidine is damaged by hydroxy radical, and is a sensitive biomarker for oxidative stress.
Anti TG monoclonal antibody specific for TG in DNA polymers.
Suitable for immunohistochemical research.
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 MTG-100P  Anti Tymidine Glycol (TG) Mc  100 µg


II Lipid Peroxidation

Isoprostane Assay Kits

Exclusivity:United States Patent Number: 5,700,654

There is strong evidence that isoprostanes are excellent molecular biomarkers for oxidant stress. Indeed, 15-F2t-Isoprostane (previously called 8-epi-PGF2a) is already widely recognized as the "gold standard" of oxidant status. Professors L. Jackson Roberts and Jason Morrow at Vanderbilt University originated isoprostanes as biomarkers for oxidative stress in vivo. We presently offer two ELISA kits for the quantification of 15-F2t-Isoprostane (8-epi-PGF2a).
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 EA84  Isoprostane EIA Kit Kit  Kit

Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 EA85  Urinary Isoprostane EIA Kit Kit  Kit






oxLDL Assay Kits

Lipid peroxidation products are formed during normal cell metabolism via producing an excess of free radicals that can react with unsaturated fatty acids, in particularly low-density lipoprotein (LDL), the major carrier of plasma cholesterol.
The binding of oxidized LDL (oxLDL) is the step by which cholesterol accumulation in macrophages is induced transforming them into lipid-loaded 'foam cells'. This process is accompanied by extensive cell proliferation and elaboration of extracellular matrix components and contributes to the genesis and progression of atherosclerosis by promoting endothelial damage and amplifying the inflammatory response within the vessel wall.

Our oxLDL ELISA Kit is intended for the quantitative determination of oxLDL in EDTA-plasma and serum.
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 K7810  OxLDL Kit  96 puits
Methods: ELISA
Standards: 25 -400 U/ml
Incubation: 4h; 1h; 10min
Sample volume: 10 µl
Sample matrix: EDTA-Plasma, Serum, Heparin Plasma


Anti 4­HNE monoclonal antibody (HNE­J2)

Highly specific for 4­HNE


Immunohistochemistry of colorectal carcinoma cells. Adenocarcinoma (arrows?) and nontumorous epithelial cells (star?;×240).
 		Membrane lipids are one of the targets of reactive oxygen species (ROS).4­hydroxy­ 2­nonenal (4­HNE) is a major membrane lipid peroxidation product. Monoclonal antibody against 4­HNE (clone HNE­J2) is highly specific for 4­HNE­His/Lys/Cys adducts. Anti 4­HNE mouse monoclonal antibody (IgG1?), lyophilized powder.
For immunohistochemistry and Western blotting
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 MHN-020P  Anti 4-HNE Mc  20 µg
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 MHN-100P  Anti 4-HNE Mc  100 µg


Hexanoyl­Lysine adduct (HEL) ELISA kit & antibody

A new biomarker of lipid peroxidation


 Hexanoyl­Lysine adduct (HEL) is a novel lipid hydroperoxide­modified lysine residues. HEL is formed by oxidative modification by oxidized ω­6 fatty acids such as linoleic acid or arachidonic acid. HEL may be a useful biomarker for initial stage of lipid peroxidation, and is detected in oxidatively modified LDL, in human atherosclerotic lesions and human urine.

ELISA kit suitable for urine and serum samples.
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 KHL-700E  Hexanoyl-Lys(HEL) ELISA kit Kit  96 puits
Suitable for human urine and animal serum. Required equipments are: pipettes, incubator and microplate reader with 450nm filter.

For immunohistochemistry and western blotting
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 MHL-020P  Anti Hexanoyl-Lys(HEL) Mc  20 µg
Anti HEL mouse monoclonal antibody (IgG, clone 5H4), lyophilized powder. Cross reactivity was checked for 8 analogues: MDA, glyoxal, methyl glyoxal, 1­hexanal, 2­hexenal, 1­nonannal, 2­nonenal and 4­hydroxy­2­nonenal.


6 - Anti MDA monoclonal antibody (1F83)

Highly specific for Malondialdehyde (MDA).


Immunohistochemical detection of MDA-modified protein in atherosclerotic aorta.
 		Malondialdehyde (MDA) is one of the major aldehyde derived from lipid peroxidation. This antibody is specific for MDA­modifird proteins, and suitable for immunohistocheistry and western blotting.

For immunohistochemistry and Western blotting.
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 MMD-030  Anti malondialdehyde (MDA) Mc  30 µg


7 - Acrolein (ACR) ELISA kit & antibody

Biomarker of lipid peroxidation.

Acrolein (ACR) is a representative carcinogenc aldehyde found ubiquitously in the environment and endogenenouslythrough oxidation reactions, such as lipid peroxidation and myeloperoxidase­catalyzed amino acid oxidation. ACR is highly reactive aldehyde and reacts with lysine residue in protein.

ELISA kit suitable for human urine.
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 KAR-200  Acrolein(ACR) ELISA kit Kit  96 puits
For immunohistochemistry and western blotting.


 Anti ACR mouse monoclonal antibody (IgG, clone 5F6). Cross reactivity was checked for 14 analogues: crotonal, 2­hexenal, 2­octanal, 2­ nonenal, 4­decanal, 2,4­decadional, MDA, 4­HHE, 4­HPE, 4­HON, 4­HNE, n­propanal, n­pentanal and n­hexenal.
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 MAR-020  Anti acrolein (ACR) Mc  20 µg


III Protection Mechanism against Oxidative stress

Test kit for Total Antioxidant Capacity (PAO)

Significance of Antioxidants.


 For accurate assessment of oxidative stress, measurement of ROS, oxidative damage and antioxidant activity may be essential. Recently, antioxidants as functional foods which scavenge ROS attract a great deal of attention. In the PAO assay kit, an easy and convenient method to measure antioxidant capacity is provided. Utilizing the reduction of cupric ion (Cu ++ ⇒ Cu + ), antioxidant capacity of samples can be detected in 5 minutes.

Application to foods, beverages and serum.

PAO can detect not only hydrophilic antioxidants such as Vitamin C, glutathione, but also can detect hydrophobic antioxidants such as Vitamin E. Applicable for assessment of total antioxidants of serum, foods and beverage samples.

Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 KPA-050E  Test kit for Antioxidant Capacity (PAO) Kit  96 puits
Suitable for human and animal serum.
Required equipments are: pipettes, and microplate reader with 492nm filter.


Glutathione Assay Kits

Glutathione (gamma-glutamylcysteinylglycine or GSH) is a naturally occurring tripeptide whose nucleophilic and reducing properties play a central role in metabolic pathways, as well as in the antioxidant system of most aerobic cells.
Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 GT20  Total Glutathione Assay Kit Kit  Kit

Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 GT10  Glutathione (GSH) Assay Kit Kit  Kit

Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 GT30  GSH/GSSG Assay Kit  Kit

Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 FR16  Human Glutathione Peroxidase Assay Kit Kit  Kit

Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 FR17  Cellular Glutathione Peroxidase Assay Kit Kit  Kit

Code Dénomination Clone Type Condi. Inf. Fiche Prix Devis
 FR19  Glutathione Reductase Assay Kit Kit  Kit
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