Domaines d'activités
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Immunologie > Facteurs de transcription
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Facteurs de transcription
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AVIVA SYSTEMS BIOLOGY (ASB) manufactures and sells premium products for applications in the fields of :
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- Transcription Factors
- Transcription Regulators
- Cell cycle Proteins
- Ions chanels
- Lymphocyte Signaling
- Membrane Proteins
- Neurobiology
- Signal Proteins
ASB combines its unique bioinformatics power for parallel and unique peptide design with enhanced antigen immunization and an mRNA profiling-guided antibody validation process that uses multiple tissue and cell samples. Thus far, ASB has manufactured over 4000 human target-specific antibodies and releases 100 new antibodies each month. More than 70 % of ASB's antibody targets are novel, lacking publications in the public domain.
Other antibodies available:
- CHRN Family antibodies
- DM Family antibodies
- FOXO Family antibodies
- IRF Family antibodies
- MCM Family antibodies
- bZIP-SUPER Family antibodies
- Connexin Family antibodies
- ENac Family antibodies
- RUNC Family antibodies
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- FOG Family antibodies
- GATA Family antibodies
- JMJD-JHDM Family antibodies
- MEF2 Family antibodies
- P2RX Family antibodies
- SIRT Family antibodies
- PAX Family antibodies
- POU Family antibodies
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ALZHEIMER
Description:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by BACE-1. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms of BACE-1 have been described. Human BACE-1 protein extra-cellular domain (from 28 AA to 393 AAB ) was expressed from E.coli and highly purified with its native enzyme activity. Purity: > 95% by SDS-PAGE. Protein concentration in package is 1mg/ml.
PHENOMENES INFLAMMATOIRES
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ANXA1 encodes a protein that belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
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