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Immunology > Endocrinology / Diabetes


[ Hormones ] - [ Obesity Diabetes ] - [ Metabolism ]




Hormones
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Advantages :    
 CE marked
 Vacuum sealed
 15 months stability
 Standardized methods
 Ready to use reagents
 Colour-coded reagents
 Adapted on fully automated systems
 Snap-off and breakable microtiterstrips
 Quantification in plasma and serum
 Quantification in saliva (steroid hormones)
      >> Thyroid Hormones
      >> Steroid Hormones
      >> Proteohormones

Steroid Hormones (Plasma/Serum)
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 DNOV001  CORTISOL kit  10 ng/ml
 DNOV002  TESTOSTERONE kit  0,1 ng/ml
 DNOV003  17 beta-ESTRADIOL kit  20 pg/ml
 DNOV004  17 OH PROGESTERONE kit  0,1 ng/ml
 DNOV005  DHEA-S kit  0,1 µg/ml
 DNOV006  PROGESTERONE kit  0,2 ng/ml
 DNOV007  FREE ESTRIOL kit  0,1 ng/ml
 DNOV008  ANDROSTENDIONE kit  0,1 ng/ml
 DNOV009  FREE TESTOSTERONE kit  0,5 pg/ml
 DNOV010  URINARY CORTISOL kit  10 ng/ml
 DNOV011  TOTAL ESTRIOL kit  1 ng/ml

Steroid Hormones (Saliva)
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 DSNOV20  CORTISOL SALIVA kit  0,5 ng/ml
 DSNOV21  TESTOSTERONE SAL. kit  5 pg/ml
 DSNOV22  17 beta-ESTRADIOL.SAL kit  2 pg/ml
 DSNOV23  17 OH PROGESTERONE.SAL kit  5 pg/ml
 DSNOV24  DHEA-S SALIVA kit  25 pg/ml
 DSNOV25  PROGESTERONE SAL. kit  10 pg/ml
 DSNOV26  ESTRIOL SALIVA kit  0,05 ng/ml


Proteohormones (Plasma/Serum)
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 DNOV030  LH kit  1 mIU/ml
 DNOV031  FSH kit  1 mIU/ml
 DNOV032  PROLACTIN kit  1 ng/ml
 DNOV033  AFP kit  2 ng/ml
 DNOV034  Beta HCG kit  0,5 mIU/ml
 DNOV035  HCG kit  1 mIU/ml


Thyroid Hormones (Plasma/Serum)
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 DNOV050  TSH kit  0,15 mIU/ml
 DNOV051  fT3 kit  0,5 pg/ml
 DNOV052  fT4 kit  0,2 ng/ml
 DNOV053  T3 kit  4,0 ng/dl
 DNOV054  T4 kit  160 ng/dl
 DNOV055  ANTI-TG kit  5,0 IU/ml
 DNOV056  ANTI-TPO kit  1,5 IU/ml
 DNOV057  THYREOGLOBULIN kit  1,0 ng/ml
 DNOV100  FERRITIN kit  2 ng/ml



Obesity Diabetes
^

He should be tested for Diabetes !!

Adiponectin

Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 aminoacid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells.
Adiponectin has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. Of particular interest is that low adiponectin serum levels predict type 2 diabetes independent of other risk factors.
Adiponectin has the potential to become a clinically relevant parameter to be measured routinely in subjects at risk for type 2 diabetes, atherosclerosis and the metabolic syndrome
Applications
  • Early indicator for diabetes type of 2
  • reliable marker for an insulin resistance
  • markers for a successful resistance therapy
  • risk marker for coronary heart illnesses
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 RD191023100  Adiponectin ELISA, high sensitive kit  96 wells/kit
 RD293023100  Adiponectin ELISA kit  96 wells/kit
Insulin

Insulin, a polypeptide hormone with a molecular weight of 5800 Da, is secreted by the beta cells of the islets of Langerhans from the pancreas. Insulin possesses a wide spectrum of biological actions. It stimulates cellular glucose uptake, glucose oxidation, glycogenesis, lipogenesis, proteogenesis and the formation of DNA and RNA. Insulin plays a key role in the regulation of plasma glucose levels (hepatic output inhibition, stimulation of peripheral glucose utilisation).

Applications
  • Determination of the beta?cell reserve during glucose tolerance test or after a carbohydrate rich meal, as a guide for the instauration of insulin therapy;
  • Contribution to the diagnosis of insulin and non-insulin?dependent diabetes;
  • Characterisation and follow?up of states of glucose intolerance;
  • Diagnosis and study of cases of insulin resistance;
  • Diagnosis of insulinoma and other causes of hypoglycemia.
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 BL-28-E  Insulin kit  96 wells
Proinsulin Intact

Proinsulin (PI), a polypeptide of 9390 MW (86 amino acids) is synthetized in the ß cells of the Islets of Langerhans in the pancreas. The level of proinsulin in serum can be a reflection of marker cell status and a consequence of disfunction of PI processing and/or secretion. Proinsulin like material is increased in clinical conditions as insulinoma, familial hyperinsulinemia, non-insulin dependent diabetes mellitus.

Applications
  • A 100% reliable marker for an advanced marker ß Cell dysfonction
  • early markers for diabetes type 2 (Earlier than the blood sugar values)
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 RD193094100  Proinsulin Intact ELISA   kit  96 wells
C-Peptide

Insulin is synthesized in the beta?cells of the islets of Langerhans as a precursor molecule, proinsulin. In the secretory granules of the beta?cells, proinsulin is cleaved into insulin and into a 31-amino?acid peptide, called the Connecting Peptide or C?Peptide. Insulin and C-Peptide are secreted in equimolar amounts. However, because of its longer half?life, the plasma concentration of C?peptide is higher than that of insulin.

The determination of plasma C?Peptide allows an assessment of the endogenous insulin production, even in the presence of exogenous insulin administration or in the presence of circulating anti?insulin antibodies

Applications
  • Assessment of residual beta?cell function in diabetics under insulin therapy
  • Detection and monitoring of the remission phase of type I diabetes
  • Adjunct in the differential diagnosis between type I (insulin?dependent) and type II (non insulin?dependent) diabetes
  • Diagnosis of insulin?induced factitious hypoglycaemia
  • Contribution to the diagnosis of insulinoma (insulin suppression test)
  • Prognostic index of foetal outcome in pregnant diabetic women
  • Evaluation of insulin secretion in liver disease
  • Monitoring of pancreatectomy
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 BL-30-E  C-PEP kit  96 wells
Acylated Ghrelin

Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach. It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that controls energy homeostasis. Ghrelin is present in the peripheral circulation under two forms: acylated and unacylated.
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 RD194062400  Acylated Ghrelin kit  96 wells
 RD394062400  Acylated Ghrelin kit  96 wells
 RD194063400  Unacylated Ghrelin kit  96 wells
 RD394063400  Unacylated Ghrelin kit  96 wells
Leptin

Leptin is produced mainly in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and body weight regulation. . In humans, leptin levels correlate with body mass index (BMI) and percentage body fat, and are elevated even in obese individuals. Leptin has a dual action; it decreases the appetite and increases energy consumption, causing more fat to be burned.
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 RD191001100  Leptin ELISA, Clinical Range kit  96 wells/kit
 RD291001200  Leptin ELISA, Clinical Range kit  96 wells/kit
Clusterin

Clusterin (Apolippoprotein J; SP-40,40; TRPM-2; SGP-2; pADHC-9; CLJ; T64; GP III; XIP8) is a highly conserved disulfide-linked secreted heterodimeric glycoprotein of 75-80 kDa but truncated forms targeted to nucleus have also been identified. Recent study demonstrate, that serum Clusterin level increases significantly in diabetic type II patients and in patients with developing coronary heart disease, or myocardial infarction. These date raise the possibility that elevated Clusterin levels in serum may represent a strong indication of vascular damage.
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 RD391034200  Clusterin ELISA kit  96 wells
EGFP-conjugated GLUT1 ligand

GLUT1 is the most widely expressed isoform of known glucose transporters and the primary glucose transporter across the blood-brain barrier. EGFP-GLUT1 ligand has been shown to bind the carboxy terminal extracellular loop of GLUT1. EGFP-GLUT1 ligand allows GLUT1 expression to be monitored at the plasma membrane of all mammalian cell lines by FACS analyses or fluorescence staining. EGFP-GLUT1 ligand can provide insights, as a qualitative and quantitative marker, into the molecular bases of both normal disordered glucose homeostasis.
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 AbC0118-1  GLUT-1 Ligand Ag  200µl / 50 assays

Metabolism
^
EGFP-conjugated GLUT1 ligand

Description:

The only detection of extra facial domain of GLUT1 on mammalian cells.

Glucose transport, as mediated by the members of the closely related glucose transporters (GLUT), plays an essential role in normal and pathological cellular metabolism. GLUT1 is the most widely expressed isoform of the known glucose transporters and the primary glucose transporter across the blood-brain barrier (1). High levels of GLUT1 expression on tumors have been associated with worse prognosis in different types of cancers, including breast and gastric carcinoma (2,3). Also, recent investigations have shown that GLUT1 mediates the transport of some glycosylated neuroactive peptidic drugs designed to cross the blood-brain barrier (4).

The recent identification of the receptor binding domain of the human T cell leukemia virus (HTLV) envelope glycoprotein (HRBD) that is necessary and sufficient to bind GLUT1 (5,6) has allowed the development of an HRBD derived peptide coupled with EGFP (EGFP-GLUT1 ligand).

EGFP-GLUT1 ligand has been shown to bind the carboxy terminal extracellular loop of GLUT1 (7) and has allowed GLUT1 expression to be monitored at the plasma membrane of all mammalian cell lines by FACS analyses or fluorescence staining (8). EGFP-GLUT1 ligand has facilitated studies of GLUT1 expression during T cell activation (9) and has been critical for the successful identification of an immature CD4+CD8+ human thymocyte population with high metabolic activity (10). Assessment of GLUT1 expression via binding of EGFP-GLUT1 ligand correlates with increased glucose uptake, as observed in malignant cancer cells or metabolically active cells (see fig 3). EGFP-GLUT1 ligand can provide insights, as a qualitative and quantitative marker, into the molecular bases of both normal and disordered glucose homeostasis.
References :
1. Hruz PW, Mueckler MM. (2001), Mol Membr Biol., 18:183-93.

2. Kang SS et al. (2002), Jpn J Cancer Res., 93:1123-8.

3. Kawamura et al. (2001), Cancer 92:634-41.

4. Guo X, Geng M, Du G. (2005), Biochem Genet., 43:175-87.

5. Manel N, Kim FJ, Kinet S, Taylor N, Sitbon M, Battini JL. (2003), Cell., 115:449-59.

6. Kim FJ, Manel N, Garrido EN, Valle C, Sitbon M, Battini JL. (2004), Retrovirology, 1:41

7. Manel N, Battini JL, Sitbon M. (2005), J Biol Chem (280):29025-9

8. Manel N, Battini JL, Taylor N, Sitbon M. (2005), Oncogene, (39):6016-25.

9. Manel N, Kinet S, Battini JL, Kim FJ,Taylor N, Sitbon M. (2003), Blood., 101:1913-18.

10. Swainson L, Kinet S, Manel N, Battini JL, Sitbon M, Taylor N. (2005), Proc Natl Acad Sci U S A., 102: 12867-72.
Figure 1: Detection of cell surface GLUT1 using the EGFPGLUT1 ligand.
Human embryonic kidney 293T cells and human erythrocytes (RBC) were incubated for 30 min at 30°C with a 1:25 dilution of EGFP-GLUT1 ligand. Staining profiles were analyzed by FACS and histograms depicting staining with « mock » protein are indicated.
Figure 2 : Cell surface expression of GLUT1 during T cell activation.
GLUT1 was detected as an early marker of human T cell activation using the EGFP-GLUT1 ligand.
Figure 3 : GLUT1 accumulation at plasma membrane and cell-to-cell junctions (arrow) of human breast carcinoma cells using the EGFP-GLUT1 ligand.
Primary mammary carcinoma cells were incubated with EGFP-GLUT1 ligand and examined by confocal immunofluorescence microscopy.
Catalog Number Description Clone Type Quantity. Inf. Data Price Quot.
 AbC0118-1  GLUT-1 Ligand Ag  200µl / 50 assays


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